Author
University of California, Los AngelesORCID 0000-0002-0161-1917Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Aleksandr M. Gorin, Noa C. Harriott, Vyas Koduvayur…·Alexander Hoffmann
This study shows that IFNγ-induced memory in macrophages relies on ongoing cytokine signaling, not epigenetic changes, as cytokine removal reverses enhancer formation and memory.
Kensei Kishimoto, Catera L. Wilder, Justin Buchanan…·Quen J. Cheng
The paper shows that high-dose IFN-β activates both ISGF3 and GAF in epithelial cells, with GAF enhancing ISGF3 target gene expression through co-localization and chromosome looping.
Quen J. Cheng, Sho Ohta, Katherine M. Sheu…·Alexander Hoffmann
This study shows that NFκB activity dynamics determine stimulus-specific epigenomic reprogramming in macrophages by promoting de novo enhancer formation.