Epigallocatechin gallate and thermal cycling-stimulation synergistically promote apoptosis in A549 cells via endoplasmic reticulum stress-induced calcium ion dysregulation and oxidative stress
Fang-Tzu Hsu, Hsu-Hsiang Liu, Yi Kung, Chieh-Jou Lin, Chih‐Yu Chao
This study shows that combining EGCG with thermal cycling-stimulation synergistically induces apoptosis in NSCLC cells through ER stress and oxidative stress, reducing EGCG dosage and toxicity.
bioRxiv · Jun 23, 2026 · PreprintCancer Biology