UBE2G1 Governs the Destruction of Cereblon Neomorphic Substrates
Gang Lu, Stephanie Weng, Mary E. Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana S. Couto, Brian E. Cathers, , Mark Rolfe
The paper identifies UBE2G1 as a critical E2 ubiquitin-conjugating enzyme required for the degradation of CRL4CRBN neomorphic substrates, showing its role in drug resistance and potential for overcoming it with next-generation compounds.
eLife · Sep 20, 2018Peer-reviewedMolecular Biology