Parallel ZNF598 and GIGYF2 pathways mediate conserved collision-dependent mRNA decay with distinct endonucleolytic features
Satoshi Hashimoto, Jennifer Sauerland, Jiahuan Zeng, Chisato Kikuguchi, Toshifumi Inada
The paper shows that two pathways, ZNF598 and GIGYF2, mediate mRNA decay due to ribosome collisions in yeast and mammals, with distinct endonucleolytic features.
bioRxiv · Jan 2, 2026 · PreprintMolecular Biology