Impaired neurogenesis and synaptogenesis in iPSC-derived Parkinson's patient cortical neurons with D620N VPS35 mutation
Ute Scheller, ChoongKu Lee, Philip Seibler, Mišo Mitkovski, JeongSeop Rhee, Christoph van Riesen
This study shows that the VPS35-D620N mutation impairs neurogenesis and synaptogenesis in iPSC-derived Parkinson's neurons, leading to synaptic dysfunction.
bioRxiv · Aug 7, 2024 · PreprintNeuroscience