JeongSeop Rhee

ATP1A3 E815K Disrupts Sodium Homeostasis and Excitability in Human Alternating Hemiplegia of Childhood Neurons

This study investigates the impact of the ATP1A3 E815K mutation on human neurons, showing disrupted sodium homeostasis and altered excitability.

Neddylation regulates the development and function of excitatory neurons

This study shows that neddylation is essential for the development and function of glutamatergic neurons, with Nedd8 deletion causing defects in dendrite complexity and synaptic transmission.

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation

This study investigates how Neuroligin-2 interacts with MDGA1 and MDGA2 to regulate gephyrin aggregation and GABAAR function in mouse hippocampal synapses, revealing MDGA1's role in modulating these processes.

Impaired neurogenesis and synaptogenesis in iPSC-derived Parkinson's patient cortical neurons with D620N VPS35 mutation

This study shows that the VPS35-D620N mutation impairs neurogenesis and synaptogenesis in iPSC-derived Parkinson's neurons, leading to synaptic dysfunction.

Pre- and postsynaptic nanostructures increase in size and complexity after LTP induction

The paper uses time-lapse super-resolution microscopy to show that pre- and postsynaptic nanostructures increase in size and complexity after cLTP induction.

Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner

This study shows that Ambra1 heterozygosity causes sex-specific reductions in excitatory synaptic activity, leading to E/I imbalance and autism-like behaviors in female mice.

The Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.

This study shows that Ube3b regulates dendritic branching and synaptic function by ubiquitinating Ppp3cc, contributing to intellectual disability-like phenotypes in a KOS mouse model.

Presynaptic PTPσ organizes neurotransmitter release machinery at excitatory synapses

This study shows that presynaptic PTPσ organizes neurotransmitter release at excitatory synapses and affects anxiety-like behaviors.

Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2

The paper identifies Kir4.1 and Connexin43 as Nedd4-2 substrates, showing their regulation impacts astrocytic function and neuronal network activity.

Correlating Synaptic Ultrastructure and Function at the Nanoscale

The paper investigates ultrastructural differences between Schaffer collateral and mossy fiber synapses to determine their contribution to functional synaptic heterogeneity.