The dynamics of ERK signaling in melanoma, and the response to BRAF or MEK inhibition, are cell cycle dependent.
Chloe M. Simpson, Nicola Ferrari, Fernando Calvo, Chris Bakal
This study shows ERK signaling in melanoma is cell cycle dependent, with distinct responses to BRAF or MEK inhibition before and after passing the restriction point.
bioRxiv · Aug 13, 2018 · PreprintCancer Biology