PPARG governs adipogenic differentiation and cell state plasticity in well-differentiated and dedifferentiated liposarcoma
Blake R. Wilde, Kyle D. Klingbeil, Francesca Day, Christopher Dann, Chris Frias, Manando Nakasaki, Sarah Dry, Fritz C. Eilber, Joseph Garfield Crompton, David B. Shackelford, Brian E. Kadera, Heather R. Christofk
This study identifies PPARG as a key regulator of adipogenic differentiation in liposarcoma, showing its loss contributes to the aggressive phenotype of dedifferentiated liposarcoma.
Science Advances · Jul 31, 2026Peer-reviewedCancer Biology