Poly(acrylamido) PEG-alternatives Enhance mRNA-LNP Efficacy in Immune Cells and Evade anti-PEG Antibodies During Repeated Dosing
Benjamin M. Fiedler, Charlotte Galley, Margarita Štrimaite, Nga Man Cheng, Najet Mahmoudi, Zhi-Ping Feng, Tammy L. Kalber, Maria-Jose Martinez-Bravo, Chris G. Morris, Jenny K.W. Lam, Daniel J. Stuckey, Gareth R. Williams, Clare L. Bennett, Pratik Gurnani
This study develops PAM-lipids as PEG alternatives for mRNA-LNPs, showing improved transfection in immune cells and evasion of anti-PEG antibodies during repeated dosing.
bioRxiv · Feb 28, 2026 · PreprintBioengineering