Thrombolysis exacerbates cerebrovascular injury after ischemic stroke via a VEGF-B dependent effect on adipose lipolysis
Ingrid Nilsson, Enming Joseph Su, Linda Fredriksson, Benjamin Heller Sahlgren, Zsuzsa Bagoly, Christine Moessinger, Christina Stefanitsch, Frank Chenfei Ning, Manuel Zeitelhofer, Lars Muhl, Anna-Lisa E. Lawrence, Pierre D. Scotney, Li Lu, Erik Samén, Heidi Ho, , Ulf Eriksson
This study shows that thrombolysis worsens cerebrovascular injury after ischemic stroke by increasing adipose lipolysis, which can be mitigated by VEGF-B antagonism.
bioRxiv · Oct 11, 2024 · PreprintNeuroscience