Genome-wide association study and sequence similarity analysis for unilateral renal agenesis using heterogeneous stock rats undercovers the KIT gene and AHR, ATF3, GATA3, HNF1B, POU2F2, and TFCP2 transcription factors as potential candidates to explain incomplete penetrance
Joel D. Leal‐Gutiérrez, Daniel B. Munro, Denghui Chen, Riyan Cheng, Tengfei Wang, Hao Chen, Paul Meyer, Keita Ishiwari, Terry E. Robinson, Christoph Rau, Michael R. Garrett
This paper identifies genetic variants and transcription factors associated with unilateral renal agenesis in rats, suggesting a threshold mechanism involving KIT and interacting transcription factors.
bioRxiv · Sep 19, 2023 · PreprintGenetics