Daniel B. Munro

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

The paper identifies non-SNP variants as significant regulators of gene expression and addiction-related traits in HS rats using joint cis-eQTL analysis.

The paper identifies genetic factors associated with balance in the elderly through GWAS and multimodal transcriptomic analysis of otolithic organs.

Trex-QTL identifies trans-eQTLs with global effects on molecular phenotypes, showing improved power and replicating known loci in rat brain data.

LaDDR improves xQTL and GWAS discovery by generating latent RNA phenotypes without requiring complete gene annotations, outperforming existing knowledge-driven methods in multiple tissues.

This study shows ivermectin reduces alcohol intake during withdrawal by enhancing GABAergic inhibition in the CeA, specifically in rats with high P2rx4 expression.

aseQC identifies low-quality samples in transcriptome data by quantifying allele-specific expression variation, improving rare variant interpretation.

RatXcan extends transcriptome-wide association studies to rats, enabling cross-species integration of GWAS and gene expression data to identify shared genetic mechanisms of complex traits.

The paper introduces Pantry, a framework for generating diverse RNA phenotypes from RNA-seq data and integrating them with genetic data, leading to increased gene-trait association discoveries.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

This paper identifies genetic variants and transcription factors associated with unilateral renal agenesis in rats, suggesting a threshold mechanism involving KIT and interacting transcription factors.

This study performs a GWAS in HS rats to identify genetic loci associated with intraocular pressure, finding three genome-wide significant loci and five candidate genes, including novel ones.

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

The paper identifies cis-QTLs and eQTLs in HS rats across five brain regions, finds colocalization with human GWAS results, and shows higher eQTL density compared to human data.

The paper identifies cell type-specific gene regulatory changes in the amygdala of rats with varying cocaine addiction-like behaviors, linking them to energy metabolism, GABAergic inhibition, and chromatin accessibility.

The paper identifies gene expression patterns in the hippocampus of rats that predict internalizing and externalizing behaviors, linking them to genetic variation and biological processes.

The paper develops ImageCCA to link histological image features with gene expression, identifying gene-morphology associations in TCGA and GTEx data.

The paper introduces a protein-centric method to aggregate exome variants for association analysis with clinical outcomes, identifying sequence units predictive of survival that conventional gene-level analysis misses.