Riyan Cheng

Genomic SEM reveals shared genetic architecture and expands locus discovery for locomotor activity in heterogeneous stock rats

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

Genome-wide association study in Heterogeneous Stock rats identifies genetic loci associated with aversion-based learning and cocaine aversion

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits

The paper identifies genetic loci associated with anxiety-like and nociceptive traits in outbred Sprague-Dawley rats using genome-wide association analysis.

Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats

The paper identifies host genetic effects on microbiome composition in rats and finds evidence of indirect genetic effects contributing to missing heritability.

Genomic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats

This study identifies genomic loci associated with cue-reactivity in rats, linking them to incentive salience and drug abuse-related traits.

A Cost-effective, High-throughput, Highly Accurate Genotyping Method for Outbred Populations

The paper describes a cost-effective, high-throughput genotyping method for heterogeneous stock rats using low-coverage sequencing data, achieving high accuracy comparable to high-coverage sequencing.

Genome-wide association study for age-related hearing loss in CFW mice

This study identifies genetic loci associated with age-related hearing loss in CFW mice using genome-wide association analysis and functional validation.

Genome-wide association study and sequence similarity analysis for unilateral renal agenesis using heterogeneous stock rats undercovers the KIT gene and AHR, ATF3, GATA3, HNF1B, POU2F2, and TFCP2 transcription factors as potential candidates to explain incomplete penetrance

This paper identifies genetic variants and transcription factors associated with unilateral renal agenesis in rats, suggesting a threshold mechanism involving KIT and interacting transcription factors.

Causal Genetic Loci for a Motivated Behavior Spectrum Harbor Psychiatric Risk Genes

The paper identifies genetic loci associated with motivated behavior in zebrafish and links them to psychiatric risk genes in humans.

Genome-Wide Association Study Finds Multiple Loci Associated with Intraocular Pressure in HS Rats

This study performs a GWAS in HS rats to identify genetic loci associated with intraocular pressure, finding three genome-wide significant loci and five candidate genes, including novel ones.

Exponential increase in QTL detection with increased sample size.

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

Genome-Wide Association Study in a Rat Model of Temperament Identifies Multiple Loci for Exploratory Locomotion and Anxiety-Like Traits

This study identifies genetic loci associated with exploratory locomotion and anxiety-like traits in a selectively bred rat model using a genome-wide association approach.

Genome-wide association study of open fieldbehavior in outbred heterogeneous stock ratsidentifies multiple loci implicated inpsychiatric disorders

This study identifies 30 genome-wide significant QTLs for open field behaviors in rats, with 13 candidate genes linked to psychiatric disorders in humans.

Genome wide association study in 3,173 outbred rats identifies multiple loci for body weight, adiposity, and fasting glucose

Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication

This study investigates replication challenges in GWAS using two mouse cohorts, finding limited replication success despite similar sample sizes and population origins.

Genome-wide associations reveal human-mouse genetic convergence and modifiers of myogenesis, CPNE1 and STC2

This study identifies genetic loci associated with muscle mass in humans and mice, finds shared genetic mechanisms, and identifies CPNE1 and STC2 as modifiers of myogenesis.