A Secreted Subunit SARS-CoV-2 RBD-CpE Yeast Oral Vaccine Induces an Adaptive Immune Response in BALB/c Mice
John Donnie Ramos, Christopher Bresnahan, Taylor V. Brysgel, Noah Kozub, Gabriel Mendoza-Rojas, Lexi Caitlin Murillo, Mark Kevin Devanadera, Josefino R. Castillo, Daniel Albert E. Castillo, Jose Paolo P. Aguilar, Marilyn G. Rimando, Nicanor Pier Giorgio Austriaco
This study develops an oral yeast vaccine using Saccharomyces boulardii expressing SARS-CoV-2 RBD-CpE, which induces RBD-specific IgG/IgA and IFN-gamma in mice.
bioRxiv · Dec 8, 2025 · PreprintImmunology