Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct
Giorgio Zenere, Chengxiang Wu, Cecily C. Midkiff, Nathan M. Johnson, Christopher P. Grice, William C. Wimley, Amitinder Kaur, Stephen E. Braun
This study identifies key structural elements in the extracellular, hinge, and transmembrane domains of an anti-HIV CAR construct that affect surface expression and cytotoxic activity.
PLoS ONE · Aug 12, 2024Peer-reviewedMolecular Biology