Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinoma
Adam S. Bryce, Silvia Martinelli, Leonor Schubert Santana, Leah Officer-Jones, Rachel L. Baird, Fiona Ballantyne, Kai Rakovic, Ian R. Powley, Dina Tataran, David J. Meltzer, Christopher Walsh, Fraser Duthie, Lucas Farndale, Adalberto Claudio Quiros, Ke Yuan, , David Kuang-Fu Chang
This study identifies architectural subtypes of PDAC using morphospatial profiling of CAFs, showing improved prognostication and chemotherapy response prediction.
bioRxiv · Feb 9, 2026 · PreprintCancer Biology