Author

Fraser Duthie

University of Bonn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:clustering· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Dagmar WachteniD· 2 shared Fieke E. M. FroelingiD· 2 shared Rainer StahliD· 2 shared Stephan B. DreyeriD· 2 shared Adalberto Claudio QuirosiD· 1 shared Adam S. BryceiD· 1 shared Agnes SchröderiD· 1 shared Aldo ScarpaiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Dagmar WachtenORCID

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Author profile →

4 papers

Recent·Most cited

Clonal evolutionary analysis reveals patterns of malignant transformation in pancreatic cancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN)

Antonio Pea, Xiaotong T. He, Rosie Upstill-Goddard, Claudio Luchini, Leonor Patricia Schubert Santana, Stephan B. Dreyer, Fraser Duthie, Nigel Balfour Jamieson, Colin J. McKay, Euan J. Dickson, Alessandra Pulvirenti, Selma Rebus, Genomics Innovation Alliance, Scottish Genome Partnership, Paola Piccoli, , David K. Chang

This study traces the clonal evolution of pancreatic cancer from IPMN using genomic and transcriptomic data, identifying two distinct evolutionary trajectories and their implications for PDAC progression.

Nature Communications · Mar 4, 2026Peer-reviewedCancer Biology

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling

Stefan Ebner, Kshiti Meera Phulphagar, Yubell Alvarez, Lars Jürgenliemke, Fabian Frechen, Isabel Stötzel, Marta Lovotti, Matthew Mangan, Anil Akbal, Niels Schneberger, Annika Frauenstein, Tabea Klein, Jonathan J. Swietlik, Benedikt O. Gansen, Diana Fink, , Felix Meissner

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

bioRxiv · Feb 25, 2026 · PreprintCell Biology

Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinoma

Adam S. Bryce, Silvia Martinelli, Leonor Schubert Santana, Leah Officer-Jones, Rachel L. Baird, Fiona Ballantyne, Kai Rakovic, Ian R. Powley, Dina Tataran, David J. Meltzer, Christopher Walsh, Fraser Duthie, Lucas Farndale, Adalberto Claudio Quiros, Ke Yuan, , David Kuang-Fu Chang

This study identifies architectural subtypes of PDAC using morphospatial profiling of CAFs, showing improved prognostication and chemotherapy response prediction.

bioRxiv · Feb 9, 2026 · PreprintCancer Biology

Potent photoswitch for expression of biotherapeutics in mammalian cells by light

Jeannette Gebel, Elisa Ciglieri, Rainer Stahl, Fraser Duthie, Andreas Möglich, Herbert Müller-Hartmann, Hanns-Martin Schmidt, Dagmar Wachten

The paper introduces a photoswitch called DEL-VPR that enables strong, light-induced gene expression in mammalian cells, surpassing constitutive promoters and improving protein production.

bioRxiv · Oct 3, 2024 · PreprintMolecular Biology