Author

Leonor Schubert Santana

University of Glasgow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:spatial transcriptomics· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Ian R. PowleyiD· 2 shared Adalberto Claudio QuirosiD· 1 shared Adam S. BryceiD· 1 shared Alejandro ReyesiD· 1 shared Amna MatlyiD· 1 shared Andrew D. CampbelliD· 1 shared Assya LegriniiD· 1 shared Aula AmmariD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

Ian R. PowleyORCID

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Author profile →

4 papers

Recent·Most cited

Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinoma

Adam S. Bryce, Silvia Martinelli, Leonor Schubert Santana, Leah Officer-Jones, Rachel L. Baird, Fiona Ballantyne, Kai Rakovic, Ian R. Powley, Dina Tataran, David J. Meltzer, Christopher Walsh, Fraser Duthie, Lucas Farndale, Adalberto Claudio Quiros, Ke Yuan, , David Kuang-Fu Chang

This study identifies architectural subtypes of PDAC using morphospatial profiling of CAFs, showing improved prognostication and chemotherapy response prediction.

bioRxiv · Feb 9, 2026 · PreprintCancer Biology

Compressed sensing expands the multiplexity of imaging mass cytometry

Tsuyoshi Hosogane, Leonor Schubert Santana, Nils Eling, Holger Moch, Bernd Bodenmiller

The paper extends compressed sensing to imaging mass cytometry, enabling higher multiplexity by recovering spatial protein expression from fewer measured channels.

Nature Communications · Nov 27, 2025Peer-reviewedBioinformatics

Epithelial Plasticity and an Immune Suppressive Microenvironment Underpin Tumour Budding in Colorectal Cancer

Phimmada Hatthakarnkul, Natalie C. Fisher, Leonor Schubert Santana, Holly Leslie, Assya Legrini, Aula Ammar, Amna Matly, Kathryn A.F. Pennel, Ian R. Powley, Courtney Bull, Peter G. Alexander, Janos Sztanko, Jean A. Quinn, Jennifer R. Hay, Hannah Morgan, , Joanne Edwards

This study identifies TNF- and TGF-β signaling as drivers of tumour budding in CRC, linked to poor prognosis and an immunosuppressive microenvironment.

bioRxiv · Mar 5, 2025 · PreprintCancer Biology

Benchmarking tools for transcription factor prioritization

Leonor Schubert Santana, Alejandro Reyes, Sebastian Hoersch, Enrico Ferrero, Christian Kolter, Swann Gaulis, Sebastian Steinhauser

This study benchmarks nine TF prioritization tools using H3K27ac ChIP-seq data from 84 perturbation experiments, identifying three top-performing tools.

Computational and Structural Biotechnology Journal · May 11, 2024Peer-reviewedBioinformatics