A scalable screening platform for phenotypic subtyping of ALS patient-derived fibroblasts
Karl Kumbier, Maike A. Roth, Zizheng Li, Julia R. Lazzari-Dean, Christopher Waters, Ping Huang, Vladislav A. Korobeynikov, Hemali P. Phatnani, Neil A. Shneider, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
The paper develops a scalable platform combining microscopy and machine learning to subtype ALS patient fibroblasts, identifying a FUS-ALS phenotypic score that correlates with age and treatment response.
bioRxiv · Sep 27, 2022 · PreprintSystems Biology