Matthew P. Jacobson

The paper develops a structure-based tool to evaluate kinase mutations in cancer by aligning them with known activating mutations using structural and functional data.

The paper investigates how pH dynamics regulate transcription factor DNA binding selectivity, finding pH-dependent binding affinities and activity for FOX family transcription factors.

The paper investigates how GTPase and kinase domain mutations in LRRK2 affect endosomal localization and Rab phosphorylation, finding that GTPase-inactivating mutants lead to more LRRK2+ endosomes and higher Rab phosphorylation.

The paper develops a scalable platform combining microscopy and machine learning to subtype ALS patient fibroblasts, identifying a FUS-ALS phenotypic score that correlates with age and treatment response.

The paper identifies 5-chloroindole as a stable analog of DHI that activates Nurr1 and promotes dopamine-related gene transcription.

The paper investigates how acetylation and phosphorylation of RNA polymerase II CTD interact through RPRD proteins, showing acetylation regulates phosphorylation and vice versa.

This study identifies granulins as regulators of lysosomal protease activity in C. elegans, showing their role in age-related protein homeostasis decline.

The paper shows BBB efflux transporters regulate endogenous steroids and behaviors, and drug interactions with these transporters cause behavioral side effects.

The paper analyzes amino acid mutation patterns across 29 cancers, identifying six mutation signatures, five of which are validated using COSMIC data.