Evaluation of K-Ras4B dimer interfaces and the role of Raf effectors
Alexios Chatzigoulas, Ioannis Andreadelis, Stefan Doerr, Christos Lamprakis, Anastasia Theodoropoulou, John I. Manchester, Camilo Velez‐Vega, José S. Duca, Zoe Cournia
This study evaluates K-Ras4B dimer interfaces and finds that Raf effectors stabilize dimers on the membrane, identifies a dynamic water channel, and suggests modulating membrane interactions as a potential therapeutic strategy.
bioRxiv · Oct 4, 2022 · PreprintMolecular Biology