Author

José S. Duca

Novartis (Switzerland)ORCID 0000-0002-0880-5618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Camilo Velez‐VegaiD· 2 shared Zoe CourniaiD· 2 shared Alexios ChatzigoulasiD· 1 shared Anastasia TheodoropoulouiD· 1 shared Christos Lamprakis· 1 shared Ioannis AndreadelisiD· 1 shared John I. ManchesteriD· 1 shared Nastazia LesgidouiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

Camilo Velez‐VegaORCID

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2 papers

Recent·Most cited

Mapping the free energy landscape of K-Ras4B dimerization

Panagiotis I. Koukos, Nastazia Lesgidou, Sepehr Dehghani‐Ghahnaviyeh, Camilo Velez‐Vega, José S. Duca, Zoe Cournia

This study maps the free energy landscape of K-Ras4B dimerization using simulations, revealing multiple interfaces and showing the G12D mutant forms more diverse dimers than wild-type.

bioRxiv · Apr 22, 2025 · PreprintBiophysics

Evaluation of K-Ras4B dimer interfaces and the role of Raf effectors

Alexios Chatzigoulas, Ioannis Andreadelis, Stefan Doerr, Christos Lamprakis, Anastasia Theodoropoulou, John I. Manchester, Camilo Velez‐Vega, José S. Duca, Zoe Cournia

This study evaluates K-Ras4B dimer interfaces and finds that Raf effectors stabilize dimers on the membrane, identifies a dynamic water channel, and suggests modulating membrane interactions as a potential therapeutic strategy.

bioRxiv · Oct 4, 2022 · PreprintMolecular Biology