Intrinsic higher potency of basal urothelial cells to intermediate and umbrella cells as the cell of origin for bladder cancer
Chuan Yu, Nicholas Chu, Alexandra Aguirre, Jonathan Green, Qing Mei Xie, Beatrice S. Knudsen, Zhu A. Wang
This study identifies basal urothelial cells as the most potent cell of origin for aggressive bladder cancer subtypes, based on lineage tracing and single-cell RNA sequencing in mouse models.
bioRxiv · Jun 28, 2025 · PreprintCancer Biology