Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
He‐Yun Hsiao, Chun‐Chia Cheng, Yu‐Ting Chou, Cheng-Chin Kuo, Wen‐Ching Wang, Bonifasius Putera Sampurna, Yi-Wen Wang, Chun-Ling Hsiao, Jing-Yiing Wu, Kuan‐Hao Lin, Wan‐Yu Yang, Yu-Hsuan Lin, Kong-Huai Gwee, Horng‐Dar Wang, Chiou‐Hwa Yuh
This study identifies the STAT3/AMPK/PFKL axis in liver cancer, showing how it promotes glycolysis and tumor growth through stabilization of PFKL and RPIA in glycolytic bodies.
bioRxiv · Feb 29, 2024 · PreprintCancer Biology