Metagenomic Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Central Nervous System Infections: A Multicentre Prospective Study
Siyuan Fan, Xiaojuan Wang, Yafang Hu, Jingping Shi, Yueli Zou, Weili Zhao, Xiaodong Qiao, Chunjuan Wang, Jerome H. Chin, Lei Liu, Lingzhi Qin, Shengnan Wang, Hongfang Li, Wei Yue, Weihe Zhang, , Hongzhi Guan
This study evaluates metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid for diagnosing central nervous system infections, finding it detects pathogens in 36.6% of cases with some false positives and negatives.
bioRxiv · Jun 10, 2019 · PreprintGenomics