Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis
Chen Wang, Cheng Ma, Shenghai Chang, Hangjun Wu, Chunlan Yan, Jinghua Chen, Yongping Wu, Shaoya An, Jiaqi Xu, Qin Han, Yujie Jiang, Zhinong Jiang, Haichun Gao, Xing Zhang, Yunjie Chang
This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.
bioRxiv · Feb 1, 2024 · PreprintCell Biology