X. Zhang

This paper develops a probiotic system for ulcerative colitis that enhances probiotic survival and colon targeting, modulates gut microbiota and immune responses, and provides a mathematical model for release dynamics.

This paper develops a reinforcement learning framework to predict downstream neural spike trains from upstream activity using behavioral rewards, achieving better behavioral performance than existing methods.

The paper introduces AggreBots, a platform for creating designer motility patterns in multicellular tissues by spatially controlling the aggregation of epithelial spheroids, achieving greater motility than traditional CiliaBots.

This study identifies BRAT1 as a key driver of glioblastoma growth and invasion, showing that its inhibition with CurD reduces tumor migration and enhances radiation sensitivity.

This study identifies BEST4 as a tumor suppressor in colorectal cancer that interacts with Hes4 to inhibit EMT and metastasis.

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

The paper shows IL-22/IL-22RA1 promotes fibroblast proliferation and fibrosis via STAT3 signaling in glaucoma patients.

This study analyzes phenotypic diversity in 43 Sect. Paeonia peony varieties using PCA, cluster analysis, and comprehensive evaluation to identify key traits influencing diversity and breeding potential.

This study shows phosphorylation of FLS2 at Ser-938 affects its dynamics and immune response by directing it to AtRem1.3 nanodomains.

This study shows that Snf1/AMPK inhibits misfolded protein import into mitochondria and promotes mitochondrial biogenesis under glucose starvation, protecting mitochondrial fitness in yeast and human cells.

PPCN, a thermoresponsive antioxidant polymer, supports islet viability and function in nonhuman primates when used for omentum transplantation.

The paper develops a deep learning framework to map genotypes to fitness, applies it to predict viral mutations and immune escape, and computes the genotype-fitness landscape for SARS-CoV-2.

This study inhibits the IST1-CHMP1B interaction in ESCRT-III, impairing endosomal recycling and inducing unconventional LC3 lipidation at stalled endosomes.

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

This study investigates how Ribisin A protects PC12 cells from H2O2-induced injury by enhancing antioxidant activity, reducing inflammation, and modulating the ERK/CREB signaling pathway.

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

This study shows that nitrite reduces the growth of Ca. Brocadia sapporoensis in anammox systems, leading to performance collapse, rather than directly inhibiting anammox activity.

This study shows that combining SHP2 inhibitor TNO155 with CDK4/6 inhibitor enhances anti-tumor activity in MPNST by restoring RB function and overcoming resistance.

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

This paper introduces AGMs for long-term in vivo molecular monitoring, demonstrating detection of dopamine and serotonin in blood and in vivo dopamine release in mice for over a week.

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.