Author

Shenghai Chang

Sir Run Run Shaw HospitalORCID 0000-0002-0908-711XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Haichun GaoiD· 2 shared Xing ZhangiD· 2 shared Chen WangiD· 1 shared Cheng MaiD· 1 shared Chunlan Yan· 1 shared Chunyou MaoiD· 1 shared Dandan SheniD· 1 shared Fulai ZhouiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPlant Biology

Haichun GaoORCID

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3 papers

Recent·Most cited

Plant BiologybioRxivPreprintFeb 9, 2025

Ultrahigh Resolution Structure of the Heat-stable Form-IAq RuBisCO from the Thermophilic Purple Sulfur Bacterium Thermochromatium tepidum

Shenghai Chang, Weiwei Wang, Michael T. Madigan…·Jing‐Hua Chen

This paper reports the ultrahigh-resolution structure of a form-IAq RuBisCO from Thermochromatium tepidum, revealing structural features contributing to its thermostability.

DOI 10.1101/2025.02.09.637349

bacteria (other)protein structure

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Cell BiologyNature CommunicationsPeer-reviewedJan 22, 2025

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

Chen Wang, Cheng Ma, Yuanyou Xu…·Yunjie Chang

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

29 citationstop 1%

mousecryo-EM

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Molecular BiologySciencePeer-reviewedMay 1, 2020

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Wanchao Yin, Chunyou Mao, Xiaodong Luan…·H. Eric Xu

This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.

1,219 citationstop 1%

virusexperimental assay

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