Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress
Li Sun, Xuejin Chen, Chunlin Song, Wenjing Shi, Libo Liu, Shuang Bai, Xi Wang, Jiali Chen, Chengyu Jiang, Shuang-min Wang, Zhouqing Luo, Ruiwen Wang, Yamei Wang, Quan‐wen Jin
The paper shows that MAPK Pmk1 in fission yeast inhibits APC/C activation by phosphorylating and degrading Slp1Cdc20 under stress, revealing a conserved regulatory mechanism.
eLife · Jun 25, 2024Peer-reviewedCell Biology