Enhancer Tuning by Sequence-Specific Repressors
Lucia Ichino, Kaelan Brennan, Benjamin J. Mallory, Tomek Swigut, Stephanie C. Bohaczuk, Jaaved Mohammed, Devaraja Gouda Mudeppa, Saman Tabatabaee, Chunyang Ni, Andrew B. Stergachis, Joanna Wysocka
This study shows that SNAI1 and SNAI2 repressors tune enhancer activity by shifting chromatin states, affecting enhancer function and evolution.
bioRxiv · Sep 14, 2026 · PreprintMolecular Biology