Saman Tabatabaee

This study shows that SNAI1 and SNAI2 repressors tune enhancer activity by shifting chromatin states, affecting enhancer function and evolution.

This study identifies xenophagocytosis as an innate immune barrier that limits interspecies chimerism and shows that blocking it enhances donor cell engraftment in mouse embryos.

The paper uses transfer learning to predict how TF dosage affects chromatin accessibility, finding that motif affinity and distribution determine sensitivity or buffering of TF concentration changes.

This study shows that organ injury accelerates stem cell differentiation by altering a Notch-Delta lateral inhibition circuit, reducing feedback delays and increasing Delta ligand levels.