A Multigenerational ''Dirty'' Mouse Model for Studying Trauma-Induced Immune Dysregulation and Infection Susceptibility
Alexandria Z. Byskosh, John F Pulford, Ekaterina Murzin, Zoe Michael, Chyna Gray Lovell, Bailin Niu, Anupamaa J. Seshadri, Gabriel A. Brat, Ashley Zajdel, Frank Borriello, James Lederer
This study shows that multigenerational 'dirty' mice have more human-like immune responses to trauma and infection than clean mice, making them better models for studying immune dysfunction.
bioRxiv · Jun 18, 2025 · PreprintImmunology