DNA replication stress redistributes the histone methyltransferase G9a and activates lineage-specific gene expression
Gillian E. Oaks, Brian T. Do, Emma M Jakubicka, Patrick J. Cunniff, Abigail P. Ward, Claire Choplick, Samantha A. Nelson, Daniel E. Bauer, Matthew G. Vander Heiden
The paper shows DNA replication stress redistributes G9a to stalled forks, activates gamma-globin genes, and explains how hydroxyurea increases fetal hemoglobin in sickle cell anemia.
bioRxiv · Oct 7, 2026 · PreprintCell Biology