Matthew G. Vander Heiden

DNA replication stress redistributes the histone methyltransferase G9a and activates lineage-specific gene expression

The paper shows DNA replication stress redistributes G9a to stalled forks, activates gamma-globin genes, and explains how hydroxyurea increases fetal hemoglobin in sickle cell anemia.

Structural insights into DHODH-mediated catalysis and drug resistance

This study provides structural insights into DHODH catalysis and drug resistance by analyzing conformational changes and resistance mutations.

Physiological folate levels constrain nucleotide synthesis and increase dependence on nucleotide salvage

This study shows that physiological folate levels limit nucleotide synthesis in leukemia cells, making them reliant on salvage pathways for proliferation.

TRANSSULFURATION LINKS ASPARTATE-ASPARAGINE METABOLISM AND REDOX HOMEOSTASIS TO DRIVE TUMOR GROWTH

This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.

Cysteine-mediated bortezomib resistance is governed by α-ketoacid availability

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

Nuclear adenosine metabolism defines a metabolic vulnerability unmasked by TP53 loss

The paper identifies a metabolic vulnerability in TP53-deficient cells linked to nuclear adenosine metabolism and histone methylation, showing its role in DNA damage response and tumor growth.

Pancreatic cancer-associated organ dysfunction promotes muscle autophagy and contributes to peripheral tissue wasting

This study shows pancreatic cancer disrupts normal pancreatic function, leading to systemic nutrient depletion and muscle wasting, with autophagy in muscle playing a key role in nutrient redistribution to support tumor growth.

Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism

This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.

Ribosome-associated quality control of aberrant protein production during amino acid limitation

The paper investigates how amino acid limitation affects translation by analyzing ribosome stalling and the role of RQC pathways and RNF14 in response to arginine depletion.

Site of breast cancer metastasis is independent of single nutrient levels

This study shows that single nutrients do not determine breast cancer metastasis sites, and identifies purine synthesis as a key factor across multiple tissues.

Acetoacetate suppresses colon cancer via an MR1-MAIT axis

This study shows that acetoacetate suppresses colon cancer by expanding and activating MAIT cells via the MR1 receptor, offering a potential immunotherapy approach.

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22

This study shows that dietary cysteine improves intestinal stem cell repair through IL-22 from CD8+ T cells.

Comparative analysis of plasma and bone marrow nutrient levels in pediatric B-ALL patients

This study compares nutrient levels in plasma and bone marrow of pediatric B-ALL patients, identifying metabolic differences between subtypes and highlighting unique metabolic features in B-ALL circulation.

Inhibition of formate production blocks CD8+ T-cell responses and delays disease onset in a mouse model of type 1 diabetes

This study shows that inhibiting formate production in CD8+ T cells delays type 1 diabetes onset in mice by reducing their activation and effector function.

Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia

This study identifies riboflavin as a critical metabolic dependency in acute myeloid leukemia, showing its role in nucleotide biosynthesis and iron-sulfur cluster metabolism beyond energy production.

Sideroflexins enable mitochondrial transport and metabolism of neutral amino acids

The paper identifies sideroflexins as mitochondrial transporters for neutral amino acids and shows functional overlap among paralogues.

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

The paper shows cancer cells adjust mitochondrial respiration to alter NAD+/NADH ratios, enhancing biomass synthesis and proliferation under nutrient limitation.

BRAF V600 and ErbB inhibitors directly activate GCN2 in an off-target manner to limit cancer cell proliferation

The paper identifies off-target activation of GCN2 by BRAF and EGFR inhibitors, showing it limits cancer cell proliferation.

Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

This study identifies sex-specific metabolic reprogramming in obesity by analyzing phosphorylation sites on metabolic enzymes and their functional impact.

ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart

This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.

Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells

The paper shows genomic uracil induces DNA replication stress without BER processing and identifies UNG2 upregulation as a vulnerability in cancer cells.

NADPH composite index analysis quantifies the relationship between compartmentalized NADPH dynamics and growth rates in cancer cells

The paper quantifies the relationship between compartmentalized NADPH dynamics and cancer cell growth rates using a composite index analysis and identifies key transporters involved in this relationship.

A metabolic map of the DNA damage response identifies PRDX1 in nuclear ROS scavenging and aspartate synthesis

The paper identifies PRDX1 as essential for DNA damage repair by scavenging nuclear ROS and regulating aspartate synthesis during the DNA damage response.

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.

Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation

This study shows that increased PHGDH expression in mice leads to premature melanin accumulation in hair follicles, suggesting a role for PHGDH in melanocyte biology and potential involvement in melanoma.