Post-transcriptional remodelling is temporally deregulated during motor neurogenesis in human ALS models
Raphaëlle Luisier, Giulia E. Tyzack, Claire E. Hall, Jamie S. Mitchell, Helen E. Devine, Doaa M. Taha, Bilal Ahmad Malik, Ione Meyer, Linda Greensmith, Jia Newcombe, Jernej Ule, Nicholas M. Luscombe, Rickie Patani
The paper identifies post-transcriptional changes during motor neurogenesis in ALS models, showing premature intron retention in VCP-mutant cells and similar effects in SOD1 and FUS mutations.
Nature Communications · May 16, 2018Peer-reviewedNeuroscience