Widespread FUS mislocalization is a molecular hallmark of ALS
Giulia E. Tyzack, Raphaëlle Luisier, Doaa M. Taha, Jacob Neeves, Miha Modic, Jamie S. Mitchell, Ione Meyer, Linda Greensmith, Jia Newcombe, Jernej Ule, Nicholas M. Luscombe, Rickie Patani
The paper investigates FUS mislocalization in ALS, finding it occurs in both VCP-mutation related and sporadic ALS, and links it to aberrant intron retention in SFPQ transcripts.
bioRxiv · Apr 9, 2019 · PreprintNeuroscience