In vivo RyR1 reduction in muscle triggers a core-like myopathy
Laurent Pelletier, Anne Petiot, Julie Brocard, Benoı̂t Giannesini, Diane Giovannini, Colline Sanchez, Lauriane Travard, Mathilde Chivet, Mathilde Beaufils, Candice Kutchukian, David Bendahan, Daniel METZGER, Clara Franzini Armstrong, Norma Beatriz Romero, John Rendu, , Isabelle Marty
This study shows that reducing RyR1 in mice causes muscle weakness, atrophy, and structural changes similar to Central Core Disease.
Acta Neuropathologica Communications · Nov 11, 2020Peer-reviewedNeuroscience