Isoform-specific characterization implicates alternative splicing in APOBEC3B as a mechanism restricting APOBEC-mediated mutagenesis
Abdul Rouf Banday, Olusegun O. Onabajo, Seraph Han-Yin Lin, Adeola A Obajemu, Joselin M. Vargas, Krista A. Delviks‐Frankenberry, Philippe Lamy, Ariunaa Bayanjargal, Clara Zettelmeyer, Oscar Flórez-Vargas, Vinay K. Pathak, Lars Dyrskjøt, Ludmila Prokunina‐Olsson
The paper shows that alternative splicing of APOBEC3B generates mutagenic and non-mutagenic isoforms, with implications for bladder cancer progression and therapeutic targeting.
Communications Biology · Mar 22, 2021Peer-reviewedGenomics