The RNA binding proteins Ddx6 and Ddx61 support development in mRNA-decay deficient pnrc2 mutants
Thomas L. Gallagher, Monica C. Blatnik, Clare C Austin, Kathryn G Thompson, Danielle M Pvirre, Ryan Denniston, Angelina Morgan, Michael G. Kearse, Sharon L. Amacher
The paper shows that Ddx6 and Ddx61 compensate for mRNA decay defects in pnrc2 mutants by regulating translation and poly(A) tail length.
bioRxiv · May 8, 2025 · PreprintDevelopmental Biology