Michael G. Kearse

This study shows that prolonged translation inhibition by cycloheximide causes proteasome-dependent degradation of ribosomal RNA and proteins, revealing a new quality control pathway called GRIP.

This study shows that an autism-linked TOP3B mutation causes mRNA covalent intermediates by disrupting metal binding in the zinc finger domain, leading to neuronal toxicity.

This study identifies m6A RNA modifications and their role in HIV-1 infection of primary CD4+ T cells, showing cell-type specific effects on PLIN3 expression and HIV-1 production.

The paper shows that Ddx6 and Ddx61 compensate for mRNA decay defects in pnrc2 mutants by regulating translation and poly(A) tail length.

This study shows KDM2B promotes ribosome biogenesis by enhancing transcription of ribosome-related genes and affects mRNA translation unequally based on mRNA features.

This study shows FMRP stalls ribosomes and promotes no-go mRNA decay of specific transcripts, revealing a new role in FXS pathogenesis.

The paper investigates how uORF length affects translation re-initiation and mRNA stability, finding that re-initiation does not robustly protect mRNAs from NMD.

This study identifies a non-canonical RNA-binding domain in FMRP that mediates translational repression without requiring mRNA G-quadruplexes.