PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth
Abigail H. Cleveland, Daniel Shiloh Malawsky, Mehal Churiwal, Claudia Rodriguez, Frances Reed, Matthew Schniederjan, José E. Velázquez Vega, Ian J. Davis, Timothy R. Gershon
This study shows that PRC2 maintains neural identity in cerebellar progenitors and medulloblastoma, but its disruption does not block medulloblastoma progression.
bioRxiv · Jul 11, 2022 · PreprintNeuroscience