Systematic mapping of enhancers, silencers, and topological elements with prime editing deletion screens
Xiangmeng Shawn Cai, Michael T. Montgomery, Masahiro Nagano, Ashna Nisal, Zhengxi Gu, Ziwei Chen, Kamal Obbad, Ruchir Rastogi, Yingxuan Tan, Tony Zeng, Maya U. Sheth, Coco Xia, Shannon Chiang, Anshul Bharat Kundaje, Anders S. Hansen, , J Engreitz
This paper introduces Swap-seq, a method to systematically delete and quantify the effects of enhancers, silencers, and topological elements on gene expression in human cells.
bioRxiv · Oct 9, 2026 · PreprintGenomics