Kamal Obbad

Systematic mapping of enhancers, silencers, and topological elements with prime editing deletion screens

This paper introduces Swap-seq, a method to systematically delete and quantify the effects of enhancers, silencers, and topological elements on gene expression in human cells.

Estrogen interactions with breast cancer risk variants in regulatory DNA

The paper identifies estrogen-modulated SNVs associated with breast cancer risk and shows their interaction with reproductive factors using polygenic risk scores.

Targeting DNMT1 augments anti-tumor CD8⁺ T cell function

This study shows that inhibiting DNMT1 improves CD8+ T cell function in the tumor microenvironment and enhances the effectiveness of immune checkpoint inhibitors in a melanoma model.

A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype

This paper shows how recombining signaling motifs creates a continuous spectrum of CAR T cell phenotypes, revealing trade-offs between memory, cytotoxicity, and safety.

Citizen-Centered, Auditable, and Privacy-Preserving Population Genomics

This paper presents a privacy-preserving framework for genomic data analysis using cryptography and blockchain, enabling secure and transparent data access for citizens.

Zebrafish Nanog is not required in embryonic cells

The study shows zebrafish Nanog is essential for extraembryonic tissue development but not directly required for embryonic cell differentiation.