Neuronal hemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein.
Santulli Chiara, Carlotta Bon, Elena De Cecco, Codrich Marta, Joanna Narkiewicz, Parisse Pietro, Fabio Perissinotto, Santoro Claudio, Persichetti Francesca, Legname Giuseppe, Espinoza Stefano, Stefano Gustincich
This study shows that neuronal hemoglobin overexpression in mice leads to dopaminergic neuron loss, cognitive deficits, and cleavage of α-synuclein.
bioRxiv · Oct 13, 2021 · PreprintNeuroscience