Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal development
Sara Jiménez, Florence Blot, A. Meunier, Rishabh Kapoor, Valérie Schreiber, Colette Giethlen, Sabitri Ghimire, Maxime M. Mahé, Nacho Molina, Adèle De Arcangelis, Gérard Gradwohl
The paper uses single-cell transcriptomics to study EEC lineage dynamics and gene regulatory networks during intestinal development in mice and humans, finding that most EECs are specified during development independently of crypt-villus structures and microbiota.
Biology Open · Oct 15, 2025Peer-reviewedDevelopmental Biology