Sara Jiménez

This study shows that MAFA promotes pancreatic islet maturation by enhancing cell growth, metabolic function, and stress resilience in stem cell-derived islets.

The paper constructs a healthy human pancreas reference atlas to contextualize disease states and benchmark models.

InterScale models both local and global cellular interactions in spatial transcriptomics data, revealing spatially restricted differentiation programs and disease-associated tissue remodeling.

This paper generates cross-species single-cell atlases of pancreatic cancer to study progression, therapy response, and immune evasion across human and mouse models.

The paper uses single-cell transcriptomics to study EEC lineage dynamics and gene regulatory networks during intestinal development in mice and humans, finding that most EECs are specified during development independently of crypt-villus structures and microbiota.

This study uses single-cell multiomics and spatial transcriptomics to identify gene regulatory programs in pancreatic cell types that drive type 1 diabetes progression.

FateCompass identifies lineage-specific transcription factors during cell differentiation using single-cell RNA-seq data, revealing known and novel regulators in mouse islet cell development and beta-like cell protocols.

The paper uses scRNA-seq and deep learning to map cell cycle gene regulation dynamics in mouse and human cells, identifying key transcription waves and transitions.

This study maps NEUROG3 occupancy in human pancreatic endocrine progenitors, identifying 1268 target genes and linking NEUROG3 to islet cell development and type 2 diabetes risk variants.

This study identifies Rfx6 as a key regulator of enteroendocrine cell differentiation, promoting peptidergic cells while repressing serotonin-producing cells.