Gérard Gradwohl

This study uses a knockout village framework to analyze how mutations in diabetes genes alter pancreatic beta cell development, revealing non-canonical cell fate shifts and identifying ISL1 as a key regulator.

The paper uses single-cell transcriptomics to study EEC lineage dynamics and gene regulatory networks during intestinal development in mice and humans, finding that most EECs are specified during development independently of crypt-villus structures and microbiota.

FateCompass identifies lineage-specific transcription factors during cell differentiation using single-cell RNA-seq data, revealing known and novel regulators in mouse islet cell development and beta-like cell protocols.

This study maps NEUROG3 occupancy in human pancreatic endocrine progenitors, identifying 1268 target genes and linking NEUROG3 to islet cell development and type 2 diabetes risk variants.

This study identifies Rfx6 as a key regulator of enteroendocrine cell differentiation, promoting peptidergic cells while repressing serotonin-producing cells.