Fat body CLOCK restrains innate immunity and maintains survival under dietary stress in Drosophila
Keisuke Fukumura, Shorbon Mowla, Vinithra Kathirvel, Colin Fang, Shreya Shekar, Annika F. Barber
This study shows that the fat body CLOCK in Drosophila suppresses inflammation and extends lifespan under dietary stress, with CLK having a unique role distinct from CYC.
bioRxiv · Jul 21, 2026 · PreprintMolecular Biology