Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci
Ákos Menyhárt, Rita Frank, Attila E. Farkas, Zoltán Süle, Viktória É Varga, Ádám Nyúl-Tóth, Anne Meiller, Orsolya Ivánkovits-Kiss, Coline L Lemale, Írisz Szabó, Réka Tóth, Dániel Zölei-Szénási, Johannes Woitzik, Stéphane Marinesco, István Adorján Krizbai, , Eszter Farkas
The paper shows that brain edema from ischemic stroke impairs glutamate clearance, leading to widespread depolarization foci and neuronal death, suggesting osmotherapy could be beneficial.
Journal of Cerebral Blood Flow & Metabolism · Aug 24, 2021Peer-reviewedNeuroscience