Ákos Menyhárt

Direct anti-inflammatory actions of N,N-dimethyltryptamine on microglia are revealed by proteomic profiling and receptor pharmacology

This study identifies DMT's direct anti-inflammatory effects on microglia through proteomic profiling and receptor pharmacology, showing it remodels inflammatory states without broadly suppressing activation.

Gαq/11 signalling counteracts endothelial dysfunction in the brain and protects cognition in aged mice

This study shows that Gαq/11 signaling in brain endothelial cells prevents endothelial dysfunction and cognitive decline in aged mice by maintaining vascular reactivity and preventing blood-brain barrier disruption.

Senolytic treatment guided by carotid stenosis confers protection against acute ischemic stroke in aged rodents

Senolytic treatment with dasatinib plus quercetin after carotid artery occlusion reduces infarct size and improves outcomes in aged rodents with ischemic stroke.

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and next generation RNA sequencing

This study shows nimodipine reduces microglial activation in vitro by altering gene expression and functional phenotypes.

Spreading depolarization causes reperfusion failure after cerebral ischemia

This study shows that spreading depolarization during ischemia predicts reperfusion failure and poor outcomes, and inhibiting it improves reperfusion.

Microglia control cerebral blood flow and neurovascular coupling via P2Y12R-mediated actions

This study identifies microglia as key regulators of cerebral blood flow and neurovascular coupling through P2Y12R-mediated mechanisms in mice and humans.

Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci

The paper shows that brain edema from ischemic stroke impairs glutamate clearance, leading to widespread depolarization foci and neuronal death, suggesting osmotherapy could be beneficial.